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Abstract Importance: Despite concern about harms related to long-term prescribed opioid use among individuals with chronic noncancer pain (CNCP), no study has examined whether the same patients engage in a risky pattern of use consistently for the long term. Objective: To examine the prevalence, incidence, persistence, and cessation of a range of opioid behaviors, indicators of extramedical use, and harm among individuals who are prescribed opioids. Design, Setting, and Participants: This 5-year prospective cohort study in communities across Australia included 1514 adults who were prescribed opioids for CNCP. Data collection took place from August 2012 to December 2018, and data analysis took place from February to November 2020. Exposure: Prescription opioid use. Main Outcomes and Measures: High-dose opioid use (≥200 oral morphine equivalent [OME] mg/d); requesting an increase in opioid dose; requesting an early prescription renewal; tampering with opioid medication; diversion of

International statistical classification of diseasesHealth problemsInternational statistical classificationRelated health problemsTenth revisionசர்வதேச புள்ளிவிவர வகைப்பாடு ஆஃப் நோய்கள்ஆரோக்கியம் ப்ராப்லம்ஸ்சர்வதேச புள்ளிவிவர வகைப்பாடுதொடர்புடையது ஆரோக்கியம் ப்ராப்லம்ஸ்பத்தாவது திருத்தம்