Starving tumors by blocking glutamine uptake eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
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IMAGE: The scientists found elevated levels of cell drinking, or macropinocytosis (green) in the stromal cells exposed to a low-nutrient environment (right), compared to normal nutrient levels that surround healthy tissue. view more
Credit: Sanford Burnham Prebys Medical Discovery Institute
Scientists at Sanford Burnham Prebys Medical Discovery Institute demonstrated for the first time that blocking cell drinking, or macropinocytosis, in the thick tissue surrounding a pancreatic tumor slowed tumor growth providing more evidence that macropinocytosis is a driver of pancreatic cancer growth and is an important therapeutic target. The study was published in Now that we know that macropinocytosis is revved up in both pancreatic cancer cells and the surrounding fibrotic tissue, blocking the process might provide a double whammy to pancreatic tumors, says Cosimo Commisso, Ph.D., associate professor and co-director of the Cell and Molecular Biology of C
Decades-Old Leprosy Drug Inhibits Coronaviruses, May Treat COVID-19 genengnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from genengnews.com Daily Mail and Mail on Sunday newspapers.
A team of researchers, including one of Indian-origin, has suggested that a leprosy drug holds promise as an at-home treatment for Covid-19.The study showed that the leprosy drug clofazimine exhibits potent antiviral activities against .
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IMAGE: Sumit Chanda, co-senior study author and director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys. view more
Credit: Sanford Burnham Prebys Medical Discovery Institute
LA JOLLA, CALIF. - March 16, 2021 - A
Nature study authored by scientists at Sanford Burnham Prebys Medical Discovery Institute and the University of Hong Kong shows that the leprosy drug clofazimine, which is FDA approved and on the World Health Organization s List of Essential Medicines, exhibits potent antiviral activities against SARS-CoV-2 and prevents the exaggerated inflammatory response associated with severe COVID-19. Based on these findings, a Phase 2 study evaluating clofazimine as an at-home treatment for COVID-19 could begin immediately.