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 E-Mail The first ever vaccine target for trypanosomes, a family of parasites that cause devastating disease in animals and humans, has been discovered by scientists at the Wellcome Sanger Institute. By targeting a protein on the cell surface of the parasite Trypanosoma vivax, researchers were able to confer long-lasting protection against animal African trypanosomiasis (AAT) infection in mice. The study, published today (26 May 2021) in Nature, is the first successful attempt to induce apparently sterile immunity against a trypanosome parasite. A vaccine was long thought impossible due to the sophisticated ability of the parasites to evade the host immune system. As well as a strong vaccine target for AAT, the findings raise the possibility of identifying vaccine targets for trypanosome species that cause the deadly human infections sleeping sickness and Chagas disease.

United kingdomUnited statesMichael pearceAndrew jacksonMatthew midgleyDelphine authemanGavin wrightSimon clareSanger instituteUniversity of glasgowWellcome sanger instituteUniversity of liverpoolUniversity of yorkAgriculture organisation of the united nationsWellcome sangerSouth america