AI technology can help prevent adverse effect of immunotherapy in certain lung cancer patients
Researchers at Case Western Reserve University, using artificial intelligence (AI) to analyze simple tissue scans, say they have discovered biomarkers that could tell doctors which lung cancer patients might actually get worse from immunotherapy.
Until recently, researchers and oncologists had placed these lung cancer patients into two broad categories: those who would benefit from immunotherapy, and those who likely would not.
But a third category patients called hyper-progressors who would actually be harmed by immunotherapy, including a shortened lifespan after treatment has begun to emerge, said Pranjal Vaidya, a PhD student in biomedical engineering and researcher at the university s Center for Computational Imaging and Personalized Diagnostics (CCIPD).
Biomarkers could help discriminate cancer therapy-associated kidney injury from other causes
A study by Mayo Clinic researchers published in
Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells.
Immune checkpoint inhibitors have improved the prognosis for patients with a wide range of malignancies including melanoma, non-small cell lung cancer and renal cancer. In some patients, this enhanced immune response may target kidney tissue, leading to acute kidney inflammation known as interstitial nephritis.
Sunshine Biopharma Signs Exclusive License Agreement With University of Georgia for COVID-19 Compounds theusnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from theusnews.com Daily Mail and Mail on Sunday newspapers.
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MONTREAL, QC / ACCESSWIRE / February 4, 2021 / Sunshine Biopharma Inc. (OTC PINK:SBFM), a pharmaceutical company focused on the research, development and commercialization of oncology and antiviral drugs today announced that it has signed an exclusive license agreement with the University of Georgia ( UGA ) for two Anti-Coronavirus compounds which UGA had previously developed and patented. Sunshine Biopharma and UGA will advance the development of these two compounds in parallel with Sunshine Biopharma s own SBFM-PL4. The next step in the development plan involves testing of the efficacy of these compounds in transgenic mice. Mice which have been genetically engineered to become susceptible to infection by SARS-CoV-2, the causative agent of COVID-19, will be challenged with the virus and subsequently treated with the test compounds to determine if progression to diseases can be arrested. Such studies are anticipated to be underway later this month.
Written by Julia Ries on February 2, 2021 Fact checked by Dana K. Cassell
Dustin Diamond received a diagnosis of lung cancer earlier this year. Noel Vasquez/Getty Images
Dustin Diamond, who was 44, was diagnosed with stage 4 small cell carcinoma, a type of lung cancer, about 3 weeks ago.
Diamond had been hospitalized early January and completed one round of chemotherapy. The disease had already spread rapidly throughout his body.
Lung cancer is most common in people over the age of 65 and is very rare in younger people.
Dustin Diamond, the actor who played Samuel “Screech” Powers in “Saved by the Bell,” died Monday, Feb. 1, just weeks after being diagnosed with cancer.