Polyphor Receives Approval to Start First-in-Human Clinical Trial of Inhaled Antibiotic Murepavadin – IT Business Net itbusinessnet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from itbusinessnet.com Daily Mail and Mail on Sunday newspapers.
MHRA approves Polyphor’s phase 1 trial of novel inhaled antibiotic
22nd December 2020
Murepavadin is in development as a precision antibiotic to treat chronic
Pseudomonas aeruginosa infections in people with cystic fibrosis (CF).
It is an outer membrane protein targeting antibiotic (OMPTA) – a novel class of antibiotics discovered by Polyphor and the University of Zurich.
The phase I study will evaluate the safety and tolerability of single and multiple ascending doses of inhaled murepavadin in healthy volunteers and will be jointly funded by Polyphor and the European Innovative Medicines Initiative (IMI).
The early-stage trial is part of Polyphor’s clinical development programme, which is aiming to explore the inhaled formulation of murepavadin to treat
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Study’s findings
Experts found that over two-thirds of children with CF infected with Covid-19 managed their symptoms at home. Of the 24 admitted to the hospital, six needed extra oxygen and two needed non-invasive ventilation.
The data also showed that most children were treated with oral or intravenous antibiotics, as is standard practice for any CF respiratory illness. A small number were given antiviral medications, and none received experimental treatments for Covid-19.
Dr Malcolm Brodlie, co-author and MRC (Medical Research Council) clinician-scientist and clinical senior lecturer, Newcastle University, said, “Our findings from our global study of 13 countries across the world reassuringly show that very few children were seriously unwell after developing Covid-19.
Gerald Henry harrisondaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from harrisondaily.com Daily Mail and Mail on Sunday newspapers.