PI3K/AKT/mTOR Inhibitors for Prostate Cancer – Finally Hints of a Breakthrough
Published 05 January 2021
Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway has been strongly linked with prostate cancer progression and metastatic potential.
1 Loss of the inhibitory phosphatase, PTEN, leading to hyperactivation of PI3K/AKT/mTOR oncogenic signaling, occurs in 40-50% of metastatic castration-resistant prostate cancer.
1,2 Not surprising is the fact that PTEN loss in patients with metastatic castration-resistant prostate cancer is associated with a worse prognosis and less benefit from androgen receptor (AR) blockade.
3 Likewise, PTEN loss and subsequent Akt activation confer radiation
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John Franklin Kincaid
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Surgery photos by Winnie Hu | UW Medicine
The right lobe of Lauren Anderson’s liver awaits transplant to her mom, Kris Anderson, on Dec. 8, 2020, at UW Medical Center.
A Washington state woman is recovering after a landmark organ transplant that she hopes will end her nearly decade-long bout with cancer. Kris Anderson, 51, of Redmond, received a lobe of liver from her daughter Lauren on Dec. 8. It was the Pacific Northwest’s first living-donor liver transplant for metastatic colorectal cancer.
Lauren Anderson, left, and her mom Kris are recovering from liver-transplant surgery.
Kris Anderson was discharged from UW Medical Center on Dec. 14, two days after Lauren. Both are recovering well at the family’s home, and both their livers will grow back to approximately 90% of original size in three months.
A year ago I had brain surgery to remove a tumor on my balance nerve, which had made everyday life a nightmare of vertigo, dizziness, headaches, and blurred vision. As best I know, the operation was a success: the troublesome tumor was plucked out of my head, and all the king’s horses and men put me back together again, almost as good as new. But they left a scar that curves up from behind my ear, sweeps over toward my forehead, and then makes a big downward turn. The knife work was done by a master, the incision clean and confident, the stitching marvelous. Yet there it is, my head scored in livid color, a question mark missing its dot.