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Automated organic synthesis made easier with capsule-based console

By Jack Washington2021-05-12T08:01:00+01:00 Chemists in Switzerland have developed a standardised console for the automated synthesis of complex organic molecules. 1 Using prepacked capsules, and requiring minimal involvement from the user, this instrument produces and purifies drug-like compounds at the push of a button. Automated organic synthesis machine Source: © Jeffrey Bode/ ETH Zurich The team behind this automated organic synthesis machine hope organic chemists will use their systemt o become developers who package their methods into integrated, user-friendly packages that can be used immediately in a safe and convenient fashion Automating chemical synthesis has been a long-standing goal in the scientific community, and with ever-increasing technological capabilities, the field has experienced vast progress in recent years. Traditionally, automated reaction systems perform simple, iterative reactions to make chain-like molecules such as peptides, DNA and oligomers. A

How Frozen May Have Solved Russia s Dyatlov Pass Mystery

The journey to Mount Ortorten in Russia s Ural Mountains was supposed to take the hiking group a few weeks. They had no reason to expect otherwise: Most of the party s college-aged members, led by 23-year-old Igor Dyatlov, were experienced skiers and hikers. After completing the journey through the mountainous wilderness, they would have qualified for the highest hiking certification granted in the Soviet Union. But the hikers never reached their destination. In February 1959, they went missing. Searchers found the first bodies the remains of five of the hikers a few weeks later. They were in a disturbing state: Some were shoeless and nearly naked in the snow. Their well-stocked tent, hundreds of yards away, had been cut open from the inside, as if they had escaped in a hurry.

Worldwide network develops SARS-CoV-2 protocols for research laboratories

 E-Mail IMAGE: Scientists Martin Hengesbach (left) und Andreas Schlundt at the nuclear magnetic resonance (NMR) spectrometre at Goethe-University Frankfurt, Germany. view more  Credit: Uwe Dettmar for Goethe-University Frankfurt, Germany FRANKFURT. When the SARS-CoV-2 virus mutates, this initially only means that there is a change in its genetic blueprint. The mutation may lead, for example, to an amino acid being exchanged at a particular site in a viral protein. In order to quickly assess the effect of this change, a three-dimensional image of the viral protein is extremely helpful. This is because it shows whether the switch in amino acid has consequences for the function of the protein - or for the interaction with a potential drug or antibody.

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