Using Stirred Tank Bioreactors for Upstream Flexibility
Sponsored Content by Pall CorporationMay 21 2021
When utilized in respect of upstream biopharmaceutical manufacturing, flexibility denotes the simplicity of setting up, scaling up, and switching between batches and various processes.
Image credit: Pall Corporation
Outstanding and enhanced flexibility is one of many key advantages of single-use systems (SUSs) and a primary reason why the adoption rate of SUS is so high. The more flexible single-use systems mean that processes can be developed and delivered a lot faster than stainless steel-based facilities.
This element is of vital importance in the global context of the race for a vaccine against COVID-19, which necessitates an industry-wide effort to hasten the development of vaccine candidates and to fundamentally support the accelerated manufacture of the billions of doses required for clinical trials and vaccination programs around the world.
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Materialization Characterization and Formulation Development
Expertise in CMC (chemistry, manufacturing, and control) ensures the appropriate manufacture of a pharmaceutical or biologic by coordinating material characterization, formulation development, and product testing for batch safety, consistency, and efficacy.
Materials characterization is a cornerstone in the understanding of the composition of a drug substance or product and its potential for efficacy or adverse biological effects when consumed.
Image Credit: DSI, a PLG Company
CMC is involved during the entire drug development process. Throughout preclinical stages, analytical methods are prepared for product monitoring. Stability testing commences, and the drug’s physicochemical properties are established. Selection and testing of the raw materials also take place.
Identifying Explosives and Residues Quickly with TOF Mass Spectrometery
Sponsored by TOFWERKMay 14 2021
Law enforcement organizations require equipment for the safe and efficient characterization of residues and explosives. An example of these compounds is the explosive triacetone triperoxide (TATP), which has been utilized in many prominent terrorist attacks and is of particular interest to law enforcement services.
Chemical ionization mass spectrometry (CI-MS) is a real-time, sensitive gas-phase analysis method that is highly capable of identifying a range of explosives at trace amounts.
When performed with the TOFWERK Vocus TOF mass spectrometer, CI-MS can quantify molecules with a broad range of vapor pressures and chemical characteristics.