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Novel immunotherapy approach targets cancers Appeared in BioNews 1086 Designer antibodies can alert the immune system to cancerous proteins, slowing tumour growth in mice – three independent studies demonstrate. Researchers at the John Hopkins University School of Medicine, Maryland, investigated the notorious cancer proteins, p53 and RAS. Mutations in p53 and RAS are common among cancers, however, drug therapies have been largely unsuccessful. Therefore, researchers aimed to develop specific antibodies, like those of our immune system, to target these proteins instead. Antibodies detect precise protein fragments, called peptides. These peptides can be presented on the cell surface when complexed with the human leukocyte antigen (HLA) proteins, said Dr Katharine Wright, lead author of one of the studies. HLA proteins present peptides to immune cells called T cells. These mutant peptide-HLA complexes serve as antigens and mark cancer cells as foreign to the immune system.

United statesKatharine wrightShibin zhouAnna wernickAlexander pearlmanJohn hopkins university school of medicineJohn hopkins university schoolProfessor shibin zhouScience immunologyScience translationalஒன்றுபட்டது மாநிலங்களில்க்யாத்ரிந் ரைட்ஷிபின் ஜூஅண்ணா வெர்னிக்அலெக்சாண்டர் முத்துஜான் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து