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Links between cardiovascular disease and cognitive decline may begin in midlife before the first clinical symptoms of either condition appear, cross-sectional data from a cohort study suggested.
Middle-age cardiovascular risk largely driven by hypertension was associated with brain hypometabolism, an imaging marker of neurodegeneration, according to Valentin Fuster, MD, PhD, of Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid, Spain, and Mount Sinai Hospital in New York City, and colleagues.
Subclinical carotid plaque burden also was tied to reduced brain metabolism independent of diabetes, hypertension, dyslipidemia, and smoking, they reported in the When brain metabolism declines, the brain s ability to handle adverse events can be compromised. Depending on the brain area affected, this can lead to a range of distinct problems, co-author Marta Cortes-Canteli, PhD, also of CNIC, said in a statement.
Feb 17, 2021
Hypertension had strongest link to midlife brain hypometabolism
What’s good for the heart is ultimately good for the brain, data from a prospective cohort study showed. The researchers noted that midlife cardiovascular risk especially hypertension in asymptomatic patients was tied to middle-age brain hypometabolism in areas known to be affected by dementia.
Subclinical carotid plaque burden was also associated with reduced brain metabolism independently of the cardiovascular disease (CVD) risk factors diabetes, hypertension, dyslipidemia, and smoking reported Valentin Fuster, MD, PhD, of Centro Nacional de Investigaciones Cardiovasculares in Madrid, Spain, and co-authors.
“The findings presented here suggest that the interplay between cardiovascular risk factors, atherosclerosis, and altered brain metabolism starts early in life,” they wrote in the
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J. Hillis Miller, 92, Dies; Helped Revolutionize Literary Studies
He was most closely associated with the Yale School, which took on the foundations of literary scholarship in the 1970s and ’80s.
The literary critic J. Hillis Miller in 2009. He was not only deconstruction’s great explicator; he was also its great defender.Credit.Jeremy Maryott
Feb. 13, 2021
J. Hillis Miller, a literary critic who, by applying the wickedly difficult analytic method known as deconstruction to a broad range of British and American prose and poetry, helped revolutionize the study of literature, died on Feb. 7 at his home in Sedgwick, Me. He was 92.