Researchers have identified a genetic pathway that could be activated to help sweep out mucus from the lungs of people with chronic obstructive pulmonary disease.
The discovery came from a series of experiments that began with amoebas single-celled organisms that extend podlike appendages to move around.
“Physician-scientists and fundamental biologists worked together to understand a problem at the root of a major human illness, and the problem, as often happens, relates to the core biology of cells,” says Doug Robinson, professor of cell biology, pharmacology, and molecular sciences, medicine (pulmonary division), oncology, and chemical and biomedical engineering at Johns Hopkins University School of Medicine.
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UT Southwestern Medical Center
April 27, 2021 – Researchers with the Peter O’Donnell Jr. Brain Institute at UT Southwestern have identified a new protein implicated in cell death that provides a potential therapeutic target that could prevent or delay the progress of neurodegenerative diseases following a stroke.
Scientists from the departments of pathology, neurology, biochemistry, and pharmacology at UTSW have identified and named AIF3, an alternate form of the apoptosis-inducing factor (AIF), a protein that is critical for maintaining normal mitochondrial function. Once released from mitochondria, AIF triggers processes that induce a type of programmed cell death.
In a study published in the journal Molecular Neurodegeneration, the UT Southwestern team collaborated with researchers at The Johns Hopkins University School of Medicine and found that, following a stroke, the brain switches from producing AIF to producing AIF3. They also reported that stroke triggers a process k
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A British minister has flatly denied a report that Prime Minister Boris Johnson said he would rather bodies piled “high in their thousands” than order a third social and economic lockdown to stem coronavirus infections.
The Daily Mail newspaper cited unidentified sources as saying that, in October, shortly after agreeing to a second lockdown, Johnson told a meeting in Downing Street: “No more … lockdowns – let the bodies pile high in their thousands.”
Defence Secretary Ben Wallace told Sky News on Monday: “It’s not true – it’s been categorically denied by practically everyone,” and added that Johnson was focused on the COVID response.