Biology of single-celled organisms reveals potential treatment target for COPD
In a series of experiments that began with amoebas single-celled organisms that extend podlike appendages to move around Johns Hopkins Medicine scientists say they have identified a genetic pathway that could be activated to help sweep out mucus from the lungs of people with chronic obstructive pulmonary disease a widespread lung ailment.
Physician-scientists and fundamental biologists worked together to understand a problem at the root of a major human illness, and the problem, as often happens, relates to the core biology of cells.
Doug Robinson, Ph.D., professor of cell biology, pharmacology and molecular sciences, medicine (pulmonary division), oncology, and chemical and biomedical engineering at the Johns Hopkins University School of Medicine
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April 14, 2021
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With the commencement of the holy month of Ramadan, most people around the world vow to use the fasting period as a means of achieving their long-standing weight loss goals so that they can flaunt their ultimate transformations on Instagram and in person when they meet, greet, and celebrate the truly magnificent festival of Eid with their loved ones.
If you’re wondering how to get that perfect summer body for a fitter, happier, active, and confident you, we have good news for you. Most people admit to trying fad diets and painstakingly exhausting workouts without understanding the metabolic mayhem and dietary upheaval our bodies already face during the month of Ramadan. Here’s what anyone trying to lose weight should know.
Federal health officials warned doctors and patients Tuesday to watch for symptoms that could indicate an extremely rare but serious form of blood clot in the brain suffered by six women who received Johnson & Johnson's coronavirus vaccine.
Credit: Johns Hopkins Medicine
Media Contact: Michael E. Newman, mnewma25@jhmi.edu
In the movie Mary Poppins, the title character sings that a spoonful of sugar helps the medicine go down. Now, Johns Hopkins Medicine researchers have shown how a radioactive sugar combined with a widely used imaging technology could soon help physicians make the medicine work better by enabling them to rapidly detect and monitor infections from the largest group of bacterial pathogens threatening humans.
The new imaging tool uses positron emission tomography commonly known as a PET scan to noninvasively find and track dangerous infections from the microbial family Enterobacterales, a group that includes the Escherichia coli strains that cause food poisoning; Klebsiella pneumoniae, a cause of pneumonia and a severe threat to patients weakened from COVID-19; and Yersinia pestis, the scourge behind the Black Death pandemic of plague in the 14th century that wiped out 75% of the world s pop
P=0.32). Two deaths occurred in each group over follow-up. Although preclinical studies targeting CaMKII have yielded mixed results, the strong mechanistic link between CaMKII and cardiac hypertrophy and failure warrants further exploration, the authors wrote.
Expressed in cardiomyocytes, CaMKII is activated by ischemia-reperfusion injury and contributes to myocyte death and dysfunction. It had been thought that a CaMKII delta inhibitor such as NP202 could halt the progression of adverse LV remodeling that may follow STEMI and result in subsequent heart failure.
Boyle and colleagues noted that their trial suffered from a higher-than-expected withdrawal rate of 23% and wound up underpowered to detect a meaningful difference in LVESVi. Patients also stayed on guideline-directed medical therapy after PCI, which could have made NP202 redundant.