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In a July 6, 2021, study published in JAMA Neurology, researchers led by UC San Francisco, Medical College of Wisconsin and Spaulding Rehabilitation Hospital followed 484 patients with moderate-to-severe TBI. They found that among the patients in a vegetative state, 1 in 4 “regained orientation” – meaning they knew who they were, their location and the date – within 12 months of their injury. “Withdrawal of life-sustaining treatment based on early prediction of poor outcome accounts for most deaths in patients hospitalized with severe TBI,” said senior author Geoffrey Manley, MD, PhD, professor and vice chair of neurological surgery at UCSF and chief of neurosurgery at Zuckerberg San Francisco General Hospital, noting that 64 of the 92 fatalities in the study occurred within two weeks of injury.

Spaulding rehabilitation hospitalUnited statesMichael mccreaGeoffrey manleyJoseph giacinoUs department of defenseEndpoints developmentUs national institutes of healthHarvard medical schoolCollege of wisconsinAmerican academy of neurologyWeill institute for neurosciencesNational institute of neurologic disordersMedical collegeZuckerberg san francisco general hospitalGlasgow outcomes scale extended