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Next-generation COVID-19 vaccine provides robust immunity against SARS-CoV-2 in mice Researchers in Canada have developed an adenoviral vector-based vaccine against coronavirus disease 2019 (COVID-19) that induced robust immune protection against the ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice. The potential next-generation vaccine candidate also induced robust immunity against the UK B.1.1.7 (alpha) and South African B.1.315 (beta) variants of concern in the animals. Furthermore, the researchers showed that respiratory mucosal administration of the vaccine was superior to the intramuscular route at inducing three-armed immunity, including local and systemic antibody responses, mucosal tissue-resident memory T cells, and mucosal trained innate immunity.

United kingdomSouth africaZhou xingUnited statesSouth africanAstrazeneca chadoxSally robertsonMcmaster universityஒன்றுபட்டது கிஂக்டம்ஜூ க்ஷிங்ஒன்றுபட்டது மாநிலங்களில்சாலி ராபர்ட்சன்மக்மாஸ்டர் பல்கலைக்கழகம்