Moderna’s COVID-19 vaccine elicits durable T cell memory and antibody responses
Researchers in the United States have shown that Moderna’s mRNA-1273 coronavirus disease 2019 (COVID-19) vaccine induces durable antibody and T cell responses to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are comparable to those seen in cases of COVID-19 caused by natural SARS-CoV-2 infection.
The spike protein is the main surface structure the virus uses to infect host cells and a primary target of neutralizing antibodies following SARS-CoV-2 vaccination or natural infection. The receptor-binding domain (RBD) of this spike mediates the initial stage of infection when it binds to the host cell receptor angiotensin-converting enzyme 2 (ACE2).
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