Brain protein helps explain link between circadian rhythm, Alzheimer’s disease
December 16, 2020 SHARE
Immune cells known as microglia (turquoise with red dots) surround a plaque of the Alzheimer’s protein amyloid (blue). The red dots indicate that the microglia are prepared to remove the potentially damaging plaque. Researchers at Washington University School of Medicine in St. Louis have discovered a protein that links the amyloid-removal process to the circadian clock. The protein, YKL-40, could help explain why people with Alzheimer’s frequently suffer from sleep disturbances, and provide a new target for Alzheimer’s therapies. (Image: Brian Lananna/School of Medicine)
Sleep Disturbances may Contribute to Alzheimers Disease by Karishma Abhishek on December 17, 2020 at 1:02 PM
Sleep disturbances like fractured sleep and daytime sleepiness are the worsening complaints of people with Alzheimer s disease (AD), as the disease progresses. But the exact link between Alzheimer s and circadian dysfunction remains masked.
A brain protein - YKL-40 that is regulated by clock genes is also a well-known biomarker of Alzheimer s disease, involved in clearing away the toxic buildup of Alzheimer s protein plaques in the brain, as per a study at Washington University School of Medicine in St. Louis published in the journal Science Translational Medicine.
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