A new collaborative study from researchers at the Geisel School of Medicine at Dartmouth and the University of Washington (UW) and published in the
Proceedings of the National Academy of Sciences (PNAS), reveals unexpected insights into how skin exposure to ultraviolet (UV) light can worsen clinical symptoms in autoimmune diseases such as lupus.
Lupus, an autoimmune disease that can cause inflammation of the joints, skin, kidneys, blood cells, brain, heart and lungs, is caused when the immune system attacks its own tissue.
Previous research has established that in up to 80 percent of lupus patients, sunlight exposure can trigger both local skin inflammation and systemic flares, including kidney disease. But little has been understood about the underlying mechanisms that drive this process.
Forum, Dec. 30: Dartmouth-Hitchcock’s priorities are flawed
Published: 12/29/2020 10:00:21 PM
Modified: 12/29/2020 10:00:14 PM
Dartmouth-Hitchcock’s priorities are flawed
I am grateful to Dominick Dephillips for speaking candidly about his mental health (“Psych care in short supply: Newport man turned away by DHMC is one example,” Dec. 24).
Thanks to West Central Behavioral Health, they found time to see him and I wish him well.
The root crisis in our inequitable health system is access to health care when we need it. The funding mechanism must change to make this happen. Since we can’t seem to rectify these problems, resources must be available where the need is great. When we hear that hospitals have been overwhelmed with COVID-19 patients, it is not the lack of beds but the lack of clinicians. This appears to be the case in Dartmouth-Hitchcock’s Department of Psychiatry.
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IMAGE: U.S. maps of participants by percentage reporting exercise change in metropolitan versus non-metropolitan areas. view more
Credit: Figure by Elise J. Laugier.
The COVID-19 pandemic has disrupted daily life, including many people s ability to exercise, which can boost mood, reduce stress and benefit one s physical and mental health. A Dartmouth study finds that pregnant women whose exercise routines were impacted by the pandemic have higher depression scores than those who have continued to exercise as usual. The study, whose findings are published in
PLOS ONE), is among the first to examine the links between COVID-19, exercise changes and prenatal depression.
Discoveries originating in a basic science lab at Geisel School of Medicine’s Department of Biochemistry and Cell Biology are being used in the newly approved COVID-19 vaccine from the Pfizer/BioNTech partnership.
Beginning in 2016, structural biologist Jason McLellan, PhD, and his colleagues at Geisel and two other prominent labs, conducted groundbreaking research on the coronavirus spike protein, the major surface protein that this type of virus uses to bind to human cells and invade them.
McLellan and his team designed a special form of the spike protein that makes it more likely to be effective as a vaccine antigen, a part of the virus that can be used to stimulate antibody production in advance, and thus help the body fight off infection.
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