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 E-Mail More than 7% of human oocytes contain at least one exchangeless chromosome pair, demonstrating a remarkably high level of meiotic recombination failure, finds a study appearing December 10 in the American Journal of Human Genetics. The findings suggest that right from the get-go of human egg cell development, a striking proportion of oocytes are predestined to be chromosomally abnormal. But the frequency of exchangeless chromosomes is not affected by maternal age. As much as anything else, this is a public service announcement, says first author Terry Hassold of Washington State University. We have known for a long time that advancing maternal age increases the likelihood of chromosomally abnormal eggs, but this observation demonstrates that many chromosome errors have nothing to do with maternal age. They are, instead, errors that are extremely common in our species, for reasons that are unclear.

United statesNational institutes of healthTerry hassold of washington state universityNovo nordisk foundationDanish national research foundationAmerican journalTerry hassoldWashington stateNational institutesDanish national researchHuman geneticsCell pressAmerican societyஒன்றுபட்டது மாநிலங்களில்தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம்டேனிஷ் தேசிய ஆராய்ச்சி அடித்தளம்