Page 3 - டேனிஷ் புற்றுநோய் சமூகம் ஆராய்ச்சி மையம் News Today : Breaking News, Live Updates & Top Stories | Vimarsana

Researchers identify long-sought enzyme that prevents cancer Researchers have found a long-sought enzyme that prevents cancer by enabling the breakdown of proteins that drive cell growth, and that causes cancer when disabled. Publishing online in Nature on April 14, the new study revolves around the ability of each human cell to divide in two, with this process repeating itself until a single cell (the fertilized egg) becomes a body with trillions of cells. For each division, a cell must follow certain steps, most of which are promoted by proteins called cyclins. Led by researchers at NYU Grossman School of Medicine, the work revealed that an enzyme called AMBRA1 labels a key class of cyclins for destruction by cellular machines that break down proteins. The work finds that the enzyme s control of cyclins is essential for proper cell growth during embryonic development, and that its malfunction causes lethal cell overgrowth. Moreover, the study further suggests that an existing

United statesDaniele simoneschiLuca businoMichele paganoEmily hendersonLangone healthDepartment of biochemistrySenior research coordinatorDanish cancer society research centerGrossman school of medicineUniversity of pennsylvaniaStanford universityHoward hughes medical instituteMolecular pharmacologyHoward hughes medicalStudy first author