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Researchers Reveal Molecular Mechanism of Ruthenium Complex Induced DNA Phase Separation

Chinese Academy of Sciences The phenomenon of “liquid-liquid” phase separation (LLPS) of biological macromolecules in living cells regulates many cell activities. DNA LLPS manipulates many important processes such as gene transcription, translation, and chromosome high-level structure assembly. Abnormity of DNA LLPS causes oncogene expression, genome inactivation, uncontrolled transcription activation and other cellular processes, which are directly related to fatal diseases. Recently, a research group led by Prof. LI Guohui from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS), in collaboration with Prof. MAO Zongwan’s group from Sun Yat-Sen University, revealed the molecular mechanism of ruthenium complex induced DNA phase separation in living cells.

National natural science foundation of chinaChinese academy of sciences illustrationDalian institute of chemical physicsSun yat sen universityJournal of the american chemical society onChinese academy of sciencesDalian instituteChemical physicsChinese academyAmerican chemical societyNational natural science foundationதேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனாடேலியன் நிறுவனம் ஆஃப் இரசாயன இயற்பியல்சூரியன் யத் சென் பல்கலைக்கழகம்இதழ் ஆஃப் தி அமெரிக்கன் இரசாயன சமூகம் ஆன்சீன கலைக்கழகம் ஆஃப் அறிவியல்

Chemical Science Symposium 2021: Biohybrid Approaches to Sustainable Energy Conversion

Chemical Science Symposium 2021: Biohybrid Approaches to Sustainable Energy Conversion
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Switzerland generalUnited statesFrance generalUnited kingdomUppsala lanStanford universitySan diegoWest bengalSouth koreaJun yaoMarc robertVincent arteroGustav berggrenMichelle changCarole dubocTobi erb

Dalian Coherent Light Source reveals strong isotope effects in photodissociation of water isotopolog

Dalian Coherent Light Source reveals strong isotope effects in photodissociation of water isotopolog
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Chemical dynamics research centerNational natural science foundation of chinaDalian institute of chemical physicsChinese academy of sciencesDalian instituteChemical physicsChinese academyDalian coherent lightScience advancesStrategic priority research programNational natural science foundationஇரசாயன இயக்கவியல் ஆராய்ச்சி மையம்தேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனாடேலியன் நிறுவனம் ஆஃப் இரசாயன இயற்பியல்சீன கலைக்கழகம் ஆஃப் அறிவியல்டேலியன் நிறுவனம்

Zero-dimensional molecular sieve membranes enhance gas separation selectivity

Zero-dimensional molecular sieve membranes enhance gas separation selectivity
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Strategic priority research programNational natural science foundation of chinaDalian institute of chemical physicsAngewandte chemie international edition onChinese academy of sciencesDalian instituteChemical physicsChinese academyAngewandte chemie international editionNational natural science foundationமூலோபாய ப்ரையாரிடீ ஆராய்ச்சி ப்ரோக்ர்யாம்தேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனாடேலியன் நிறுவனம் ஆஃப் இரசாயன இயற்பியல்சீன கலைக்கழகம் ஆஃப் அறிவியல்டேலியன் நிறுவனம்இரசாயன இயற்பியல்

Study Sheds Light on Precise Personalized Hepatocellular Carcinoma Medicine

Chinese Academy of Sciences A research group led by Prof. PIAO Hailong from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) identified hepatocellular carcinoma (HCC) subtypes with distinctive metabolic phenotypes through bioinformatics and machine learning methods, and elucidated the potential mechanisms based on a metabolite-protein interaction network and multi-omics data. The study, published in Advanced Science on July 11, provides insights guiding precise personalized HCC medicine. Metabolic reprogramming, which can promote rapid cell proliferation by regulating energy and nutrient metabolism, is considered to be one hallmark of cancer. It can impact other biological processes through complex metabolite-protein interactions.

Hai longChinese academy of sciences identificationDalian institute of chemical physicsChinese academy of sciencesDalian instituteChemical physicsChinese academyAdvanced scienceஹாய் நீண்டதுடேலியன் நிறுவனம் ஆஃப் இரசாயன இயற்பியல்சீன கலைக்கழகம் ஆஃப் அறிவியல்டேலியன் நிறுவனம்இரசாயன இயற்பியல்சீன கலைக்கழகம்