Size matters: Bimodal imaging receives nanoparticle enhancement
A nanoparticle s size is fine-tuned to offer high-resolution images before and during surgical procedures.
Tsukuba, Japan, Mar 10, 2021 - (ACN Newswire) - Scientists have found a way to control the size of special nanoparticles to optimize their use for both magnetic resonance and near-infrared imaging. Their approach could help surgeons use the same nanoparticles to visualize tumours just before and then during surgery using the two different imaging techniques. Their findings were published in the journal Science and Technology of Advanced Materials.
The scientists injected the nanoparticle solution into the tail veins of live mice and were able to obtain high quality MRI (L) and near-infrared fluorescence (R) scans of tissues and blood vessels.
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Size matters: Bimodal imaging receives nanoparticle enhancement
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ACS announces first open access read and publish agreement in Japan, partnering with Tokyo University of Science
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Scientists from Japan and the United States have identified a new mechanism of blood-brain barrier degradation in the post-stroke brain, involving acrolein-induced modifications of proheparanase. This discovery could lead to the production of newer and more effective drugs for stroke-related disorders. Credit: Toubibe from Pixabay Read Time:
The blood-brain barrier prevents immune cells from circulating freely in the brain, and the breakdown of its function is a major cause of post-stroke inflammation. Now, for the first time, researchers have identified how a toxic stroke byproduct, acrolein, could activate the barrier-degrading enzyme proheparanase (proHPSE). The research group has discovered that proHPSE degrades the glycocalyx within the post-stroke brain s blood vessels, providing hope for new and effective therapeutics against post-stroke inflammation.