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IMAGE: New SaferSeqS technology detects rare mutations in blood in a highly efficient manner and reduces the error rate. view more
Credit: Elizabeth Cooke
Next-generation gene sequencing (NGS) technologies in which millions of DNA molecules are simultaneously but individually analyzed theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream. Identifying such mutations enables earlier diagnosis of cancer and can inform treatment decisions. Johns Hopkins Kimmel Cancer Center researchers developed a new technology to overcome the inefficiencies and high error rates common among next-generation sequencing techniques that have previously limited their clinical application.
To correct for these sequencing errors, the research team from the Ludwig Center and Lustgarten Laboratory at the Johns Hopkins Kimmel Cancer Center developed SaferSeqS (Safer Sequencing System), a major improvement to widely used tec
Research Article
Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study
Jeanne Tie , Contributed equally to this work with: Jeanne Tie, Yuxuan Wang Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America ⨯
Joshua Cohen,
Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America
Affiliation Sidney Kimmel Co
(Lia Shaked)
Health technology company Carevive which developed a platform that helps clinicians create personalized treatment plans for cancer patients won a new major backer last month.
The company banked a series C equity investment of $18 million with support from Philips Health Technology Ventures. Phillips joined prior investors HLM Venture Partners, LRVHealth, Cerner and founder Madelyn Trupkin Herzfeld in the round.
Carevive s platform allows clinicians to tailor cancer care management programs for each patient s needs, informed by real-world patient experiences and outcomes, not just clinical data. Its remote symptom management system means patients need to take fewer trips to health centers. And Carevive s data and analytics are helping researchers design innovative cancer care delivery models, payers to reimburse treatments effectively and life science companies to develop personalized therapies for cancer.