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Cells sense and respond to the mechanical properties of the cellular microenvironment in the body. Changes in these properties, which occur in a number of human pathologies, including cancer, can elicit abnormal responses from cells. How the cells adapt to such changes in the mechanical microenvironment is not well understood.
A team of researchers at Texas A&M University are working to understand cellular mechanosensing the ability to sense and respond to the mechanical properties of the microenvironment in a unique way. Dr. Tanmay Lele, Unocal Professor in the Department of Biomedical Engineering, Department of Chemical Engineering and the Department of Translational Medical Sciences, partnered with Dr. Charles Baer, an evolutionary biologist at the University of Florida. Together they used methods of experimental cellular evolution as a means to understand cellular adaptation to biomaterials of controlled mechanical properties.
Researchers from across campus receive 2021 global health grants and awards wisc.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from wisc.edu Daily Mail and Mail on Sunday newspapers.
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IMAGE: Aaliyah Shodeinde, a fourth-year graduate researcher in the McKetta Department of Chemical Engineering working in professor and drug delivery pioneer Nicholas Peppas lab. view more
Credit: The University of Texas at Austin
Viruses attack the body by sending their genetic code DNA and RNA into cells and multiplying. A promising class of therapeutics that uses synthetic nucleic acids to target and shut down specific, harmful genes and prevent viruses from spreading is gaining steam.
However, only a handful of siRNA, or other RNA interference-based therapeutics have been approved. One of the main problems is getting the siRNA into the body and guiding it to the target.
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IMAGE: These results suggest that the cyclin D2-cardiomyocyte transplantation may be a potential therapeutic strategy for the repair of infarcted hearts, said study leader Jianyi Jay Zhang, M.D., Ph.D., the chair. view more
Credit: UAB
BIRMINGHAM, Ala. - In a large-animal study, researchers have shown that heart attack recovery is aided by injection of heart muscle cells derived from human induced pluripotent stem cell line, or hiPSCs, that overexpress cyclin D2. This research, published in the journal
Circulation, used a pig model of heart attacks, which more closely resembles the human heart in size and physiology, and thus has higher clinical relevance to human disease, compared to studies in mice.
Society selects students for their outstanding scholarly achievement and commitment to advocacy and to fostering diversity By Saralyn Cruickshank / Published May 14, 2021
Five Johns Hopkins graduate students have been selected to join the university s chapter of the Edward Alexander Bouchet Graduate Honor Society, which recognizes outstanding scholarly achievement and promotes diversity and excellence in doctoral education and the professoriate.
The Bouchet Society seeks to develop a network of scholars who exemplify academic and personal excellence, foster collegial and inclusive environments, and serve as examples of scholarship, leadership, character, service, and advocacy for students who have been traditionally underrepresented in higher education. The society is named for Edward Alexander Bouchet, who in 1876 became the first African American to receive a doctoral degree in the United States.