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06 May 2021
Researchers have created a probe that glows when it detects an enzyme associated with issues that can lead to blood clots and strokes.
The team of researchers, from the Department of Chemistry and the National Lung and Heart Institute at Imperial College London, demonstrated that their probe quickly and accurately detects the enzyme in modified E. Coli cells.
This new probe will provide real-time and easily measured responses to diagnostic enzymes. Professor Nicholas Long
They are now expanding this proof-of-concept study, published in
the Journal of the American Chemical Society and funded by the British Heart Foundation (BHF), with the hope of creating rapid tests for cardiovascular problems and a new way to track long-term conditions.
Glowing Probe can detect Heart Diseases Earlier by Angela Mohan on May 6, 2021 at 9:56 AM
They study published in the
Journal of the American Chemical Society was funded by the British Heart Foundation (BHF), for creating rapid tests for cardiovascular problems and a new way to track long-term conditions.
Intraplaque haemorrhages (IPHs) can occur during atherosclerosis when portions of the plaque break away from the artery walls. They can form more vulnerable plaques and blood clots, restricting blood flow to the heart and the brain and potentially leading to chronic diseases or catastrophic events like strokes.
Detecting IPHs provide a warning system and allow early diagnosis of vascular conditions. The research team designed a chemical probe that can detect rises in levels of an enzyme that accompanies IPHs and even plaque instabilities that precede IPHs.
Credit: Angelo Frei / Imperial College London
Researchers have created a probe that glows when it detects an enzyme associated with issues that can lead to blood clots and strokes.
The team of researchers, from the Department of Chemistry and the National Lung and Heart Institute at Imperial College London, demonstrated that their probe quickly and accurately detects the enzyme in modified E. Coli cells.
They are now expanding this proof-of-concept study, published in the
Journal of the American Chemical Society and funded by the British Heart Foundation (BHF), with the hope of creating rapid tests for cardiovascular problems and a new way to track long-term conditions.
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