Ces erreurs génétiques qui pourraient façonner notre espèce bbc.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bbc.com Daily Mail and Mail on Sunday newspapers.
DNAJC9 protein plays a key role in safeguarding histones, shows study
In the cell nucleus histones play a crucial role packaging DNA into chromatin. Histones are however very sticky to both DNA and RNA, so to ensure they are transported to the cell nucleus after synthesis and bind to the right portion of DNA to organize the chromatin, they are guarded by complexes of histone chaperones.
Histone chaperones are proteins that bind to histones to help protect them from non-specific binding events until they reach their goal. This process fails sometimes and histones get stuck during their supply to chromatin without any purpose.
French studio Dominique Perrault Architecture and local architect Zhubo Design are set to design a university campus with a 700-metre-long building for the Shenzhen Institute of Design and Innovation.
Set to be built in a valley at the base of Phoenix Mountain, Dominique Perrault Architects and Zhubo Design s campus will contain academic buildings, public squares, gardens, sheltered promenades as well as student and teacher housing.
Top: Shenzhen Institute of Design and Innovation by Dominique Perrault Architects and Zhubo Design. Above: a 700-metre-long building will stretch along the base of the mountain
The 300,000 square-metre campus for the Shenzhen Institute of Design and Innovation aims to become a local landmark and will feature a 700-metre linear building.
Protein can release trapped histones in the cell eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
08 Apr 2021
A toxic brew of lysosomal lipids, reactive iron atoms, and oxidative stress can spell doom for human neurons. This is the upshot of the first-ever CRISPR screens at the genome-wide level in these cells. Researchers led by Martin Kampmann at the University of California, San Francisco, used the genome-editing tool to dial up or down expression of each protein-coding gene in the human neuronal genome. They uncovered a surprising connection between endolysosomal processing and the iron-dependent cell-death pathway called ferroptosis.
First genome-wide CRISPR screens in human neurons tweaks gene expression.
Endolyosomal function, oxidative stress, and iron homeostasis genes key to neuronal survival.