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IMAGE: Graphic illustration of the work: DNA-programmed affinity labelling (DPAL) enables the direct screening of DNA-encoded chemical libraries (DELs) against membrane protein targets on live cells to create novel drug discovery. view more
Credit: The University of Hong Kong
A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.
Membrane proteins play important roles in biology, and many of them are high-value targets that are being intensively pursued in the pharmaceutical industry. The method developed by Dr Li s team provides an efficient way to discover novel ligands and inhibitors against membrane proteins, which remain largely intract
Novel method to quantify decomposition of rhizodeposits
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Covid-19 : un laboratoire a lui tout seul ?
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IMAGE: By coupling a large-scale hydrological model with a local-scale, high-resolution hydraulic model and urban flood model while integrating multiple sources of ground and satellite remote sensing data, a Glocal (global. view more
Credit: Advances in Atmospheric Sciences
Large-scale global forecasting and on-the-ground observations need to meld into one system to better predict and prevent wide-spread flooding disasters, according to an international research team who published a short view in A glocal global to local hydrometeorological solution for floods is considered to be critical for better preparedness, mitigation, and management of different types of significant precipitation-caused flooding, which happen extensively almost every year and in many countries, such as China, India and the United States, said paper author Huan Wu, professor and deputy director in the Guangdong Province Key Laboratory for Climate Change and Natural Disaster