Ultrasound Offers Focused Noninvasive Option for Neuropsychiatric Disorders
Noninvasive focused ultrasound stimulation with cell-type specificity. Source: College of Engineering, Carnegie Mellon University
May 7, 2021
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Neuromodulation, a therapeutic approach used in the treatment of neurological disorders such as Parkinson’s disease, epilepsy, and insomnia, delivers controlled physical energy to the patient’s nervous system. However, currently used clinical neuromodulation techniques are either invasive, such as deep brain stimulation where electrodes must be implanted into the brain, or unfocused, such as transcranial current stimulation where electrodes are placed on the head.
Scientists now report a precise, noninvasive, and reversible neuromodulation technology that transmits low-intensity transcranial focused ultrasound (tFUS) pulses through the skull with high spatial resolution and selectivity at targeted brain regions that can be tuned to activate or deactivate
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VIDEO: This video is a map of edge density, a measure of the density of white matter connections between different brain regions. The color scale goes from dark purple where there. view more
Credit: Justin Reber, University of Iowa
A new University of Iowa study challenges the idea that gray matter (the neurons that form the cerebral cortex) is more important than white matter (the myelin covered axons that physically connect neuronal regions) when it comes to cognitive health and function. The findings may help neurologists better predict the long-term effects of strokes and other forms of traumatic brain injury.
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New research from Carnegie Mellon University s Bin He demonstrates that noninvasive neuromodulation via low-intensity ultrasound can have cell-type selectivity in manipulating neurons.