Chinese Academy of Sciences
Recently, the research group led by Prof. YU Ziniu from the South China Sea Institute of Oceanology (SCSIO) of the Chinese Academy of Sciences sequenced the first complete Natuilus genome and unveiled the evolutionary features underlying the pinhole eye formation and biomineralization.
This study was published in Nature Ecology & Evolution on May 10.
Nautilus is the only surviving externally shelled cephalopod since the Palaeozoic. They have preserved many ancestral features despite a long evolutionary history, such as a chambered shell and pinhole eye.
The researchers sequenced the complete genome of N. pompilius, which is the most widespread species among nautiluses. The genome was 730.58 (Mb) in size and encoded 17,170 protein-coding genes, presenting a most compact, simple and slow-evolving genome when compared to other coleoid cephalopods.
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IMAGE: Thermal imaging shows how a square of the new textile (dashed lines) traps heat in heating mode (top), while reflecting it in cooling mode (bottom). view more
Credit: Adapted from
2021, DOI: 10.1021/acs.nanolett.1c00400
Clothing, from tank tops to parkas, helps people adapt to temperatures outdoors. But you can only put on or take off so much of it, and fluctuations in weather can render what you are wearing entirely inadequate. In a new study in ACS
Nano Letters, researchers describe a high-tech alternative: a reversible textile they designed to trap warmth in the cold and reflect it during hot weather, all while generating small amounts of electricity.
Cd86), were down-regulated in
Mettl3-deficient cells (Fig. 1G), suggesting that METTL3 has a critical function in controlling the innate immune response of Raw 264.7 macrophages.
To further confirm the biological role of the m
6A modification in macrophages,
Mettl3 conditional KO (CKO) mice were generated by crossing
Mettl3
flox/flox mice with mice expressing Cre recombinase under the control of lysozyme 2 promoter (
Lyzm-Cre). We have documented the loss of both the METTL3 protein and the overall m
6A modification in bone marrow–derived macrophages (BMDMs) from
Mettl3
flox/flox;
Lyzm-Cre mice (fig. S1I). No differences in the frequency of major immune cell populations were observed between
Chinese Academy of Sciences
Nicotinamide adenine dinucleotide (NAD), an indispensable cofactor in cells, participates in diverse redox biochemistry and other nonredox processes. NAD level variation leads to global yet difficult-to-predict biological responses.
A research team led by Prof. ZHAO Zongbao from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences has committed to developing non-natural cofactor-based systems to avoid the limitation associated with NAD level fluctuation.
The team has designed a non-natural coenzyme nicotinamide cytosine dinucleotide (NCD), and engineered a series of oxidoreductases. However, it’s still challenging for microbial cells to take NCD from the environment.