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Brasilia [Brazil], May 26 (ANI): A research group at Sao Paulo State University (UNESP) has analyzed how Candida albicans fungi and Staphylococcus aureus bacteria influence gene expression and tumour cell survival.
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Credit: FOAr-UNESP
An
in vitro study conducted by a group of researchers at São Paulo State University (UNESP) in Araraquara, Brazil, shows how fungi and bacteria can activate genes associated with head and neck tumors, as the metabolism of biofilms (communities in which these microorganisms self-organize in a structured and coordinated manner) stimulate tumor cells by favoring the cell signaling pathways required for tumor development and resistance to treatment. The findings include entirely novel information on the links between microbial biofilms and cell behavior in head and neck cancer.
The researchers discovered that metabolites secreted by biofilms, termed the secretome, can modulate the expression of proto-oncogenes and cell cycle genes associated with tumor cell growth and survival. Their analysis of gene expression focused on two signaling pathways (EGFR/RAS/RAF/MEK/ERK and EGFR/PI3K/AKT/mTOR) that play a key role in tumor cell proliferation, differentiation
Interdisciplinary Approach Effectively Treats Obesity by Angela Mohan on May 21, 2021 at 10:45 AM
Interdisciplinary clinical measures like cognitive and behavioral therapy may produce more significant outcomes for obese people, reducing weight and also symptoms of depression.
This is the main conclusion of a study conducted in Brazil by the Obesity Research Group at the Federal University of São Paulo (UNIFESP) in Santos, São Paulo state, and published in the journal
Frontiers in Nutrition.
Considered one of the world s major public health problems, obesity has more than doubled in Brazil in 17 years and is now increasingly frequent among children and young adults. Between 2002 and 2019, the proportion of obese adults rose from 12.2% to 26.8%. Among women, it reached 29.5% (versus 21.8% among men).
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IMAGE: The study showed that interdisciplinary action facilitates weight loss, improves quality of life and eating behavior, and reduces symptoms of depression view more
Credit: Suzana Maria Rossi Teixeira
Quality of life relating to physical and mental health can be a key element in the treatment of obese adults. For this reason, interdisciplinary clinical measures including cognitive and behavioral therapy may produce more significant outcomes for these people, reducing not just weight but also symptoms of depression.
This is the main conclusion of a study conducted in Brazil by the Obesity Research Group at the Federal University of São Paulo (UNIFESP) in Santos, São Paulo state, and