New blood markers may reveal heart attack in chest patients shanghainews.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from shanghainews.net Daily Mail and Mail on Sunday newspapers.
Background: Pulmonary arterial hypertension (PAH) is an incurable disease that urgently needs therapeutic approaches. Based on the therapeutic effects of fasudil and dichloroacetate (DCA) on PAH, we aimed to explore the effects and potential mechanism of a new salt, fasudil dichloroacetate (FDCA), in a SU5416 plus hypoxia (SuHx)-induced rat model of PAH.
Methods: The rat model of PAH was established by a single subcutaneous injection of SU5416 (20 mg/kg) followed by hypoxia (10% O
2) exposure for 3 weeks. FDCA (15, 45, or 135 mg/kg i.g. daily) or the positive control, bosentan (100 mg/kg i.g. daily), were administered from the first day after SU5416 injection. After 3-week hypoxia, hemodynamic parameters, and histological changes of the pulmonary arterial vessels and right ventricle (RV) were assessed. Additionally, in vitro, the effects of FDCA (50 μM), compared with equimolar doses of fasudil, DCA, or fasudil+DCA, on the proliferation, migration, and contraction of human pulmona
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Patients with breast cancer with distant lymph node metastases (DLNM) had similar survival to that of patients with regional node involvement and significantly better survival than those with non-DLNM distant spread, an analysis of 2,000 cases showed.
Women with DLNM at diagnosis had a 3-year breast cancer-specific survival (BCSS) rate of 64.54% versus 63.24% for patients with ipsilateral supraclavicular lymph node metastases (ISLM) and 41.20% for those with distant metastases. Overall survival (OS) at 3 years was also similar between ISLM and DLNM, but significantly worse for patients with non-DLNM distant metastases.
The results, derived from Surveillance, Epidemiology, and End Results (SEER) registry data, suggest that DLNM should be considered regional disease warranting aggressive treatment, reported Wenbin Zhou, MD, PhD, of Nanjing Medical University in China, and co-authors in
Chinese political advisor proposes to tighten admission standards for international students
Chen Xi Published: Mar 07, 2021 11:59 PM
International students take a photo at the graduation ceremony of Nanjing Medical University on June 30, 2019. Photo: CFP
A proposal to tighten admission standards for international students in China has gained support among Chinese netizens. However, experts noted that China is making certain strategic adjustments in the enrollment of international students.
The proposal was made by Gao Yanming, Chairman of Hebei Ocean Shipping Company in Hebei Province and also a member of the National Committee of Chinese People s Political Consultative Conference (CPPCC).
Gao proposed that all international students should meet the required credits for admission with the exception of those funded by foreign governments, who can have lower admission scores. Chinese universities should not blindly pursue a quota of enrolled students while ignoring the qualit