Progress in personalised renal dosing
14th January 2021
Decreased kidney function, whether the result of chronic kidney disease or acute injuries to the kidney, can substantially alter the removal of drugs from the body, leading to toxicity or even, in some cases, less effectiveness.
Approximately 13.4% of the world’s population has chronic kidney disease (with ~3 million people in the UK affected), and the incidence rises in older adults, where 24-36% of patients ≥ 65 years of age are impacted. Decreased kidney function is often overlooked clinically, particularly in younger patients, but new, acute-onset kidney impairment can occur at any time due to medication, illness, or trauma.
Research Article
Long-term health outcomes of people with reduced kidney function in the UK: A modelling study using population health data
Iryna Schlackow , Contributed equally to this work with: Iryna Schlackow, Claire Simons Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom Contributed equally to this work with: Iryna Schlackow, Claire Simons Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Nuffield Department of Population Health, University of Oxford, Oxford, United
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