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Existing drug could treat aggressive triple-negative breast cancer – study | Burnham and Highbridge Weekly News

An already approved cancer drug could be used to treat more aggressive forms of breast cancer, new research has found. Researchers funded by Breast Cancer Now have identified a specific defect in some triple-negative breast cancers and a pre-existing drug that could help treat the disease. The new research, led by Dr Rachael Natrajan at The Institute of Cancer Research, discovered a way to identify triple-negative breast tumours that could be more likely to respond to a class of drugs called CDK4/6 inhibitors, including palbociclib. Palbociclib is currently used to treat other breast cancers that have spread to a different part of the body. However, the research found there is the potential to use the drug to treat around a fifth of people living with triple-negative breast cancer.

Medical breakthrough could help thousands in UK living with an aggressive type of breast cancer

Medical breakthrough could help thousands in UK living with an aggressive type of breast cancer Maya Oppenheim © Provided by The Independent Thousands of women living in the UK suffering from an aggressive type of breast cancer could be helped by a newly identified drug, according to a study. The research, carried out by The Institute of Cancer Research, found medicine presently used to help other breast cancers that have spread to another area of the body, could actually be utilised to help around a fifth of women who have triple negative breast cancer. Around 55,000 women are diagnosed with breast cancer in Britain each year, with approximately one in five of these being triple negative. Younger women and black women are more likely to develop this form of breast cancer which is generally more aggressive.

Aggressive breast cancers could be fought with drug already being used in treatment

The medication is currently used on other breast tumours that have spread through the body. But the researchers found the potential to use it to treat around a fifth of people with triple-negative breast cancer. Dr Natrajan said the study “suggests the exciting possibility that an already-approved breast cancer drug could be used to help women with this type of disease”. Clinical trials will take several years but if they are successful, CDK4/6 inhibitors could be used within five years. Triple-negative breast cancer refers to tumours lacking three molecules normally used to classify it – oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) protein. 

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