Using estrogen to target drug-resistant breast cancer in mice
Researchers at Dartmouth s and Dartmouth-Hitchcock s Norris Cotton Cancer Center (NCCC) hope to make estrogen therapy a more accessible treatment option for breast cancer patients who could benefit from it.
Anti-estrogen treatments, which block growth signals from estrogen receptors (ER) in tumors, are effective treatments for ER+ breast cancer. But it is common for breast tumors to become resistant to anti-estrogen treatments over time.
The research team, led by molecular biologist Todd Miller, PhD, and Nicole Traphagen, a PhD candidate in the Miller Laboratory, found that in mice, cycling between estrogen treatment and anti-estrogen treatment at a specific point in time can dramatically increase the duration of tumor regression.
Targeting drug-resistant breast cancer with estrogen eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
April 15, 2021 by Office of Communications
Three teams receive awards from the Dartmouth Innovations Accelerator for Cancer.
Project Leads for the team winning the top award are, from left, Arti Gaur, assistant professor of neurology at Geisel; Divya Ravi, Guarini ’24, and Jordan Isaacs, Guarini ’24, both PhD students in the Cancer Biology Program. (Photo by Kata Sasvari)
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Three teams of Dartmouth researchers have been selected to receive the first awards from the Dartmouth Innovations Accelerator for Cancer.
A philanthropy-funded initiative, the Accelerator was launched in 2020 by Norris Cotton Cancer Center and the Magnuson Center for Entrepreneurship to bring new cancer treatments to patients more quickly. So far, it has raised $3.3 million in philanthropic gifts and seeks to hit $5 million by June.
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IMAGE: Project leads for the team winning the top award are, from left, Arti Gaur, assistant professor of neurology at Geisel; Divya Ravi, Guarini 24, and Jordan Isaacs, Guarini 24, both. view more
Credit: (Photo by Kata Sasvari
Three teams of Dartmouth researchers have been selected to receive the first awards from the Dartmouth Innovations Accelerator for Cancer.
A philanthropy-funded initiative, the Accelerator was launched in 2020 by Norris Cotton Cancer Center and the Magnuson Center for Entrepreneurship to bring new cancer treatments to patients more quickly. So far, it has raised $3.3 million in philanthropic gifts and seeks to hit $5 million by June.
Philanthropy-Backed Accelerator Advances Cancer Therapies dartmouth.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dartmouth.edu Daily Mail and Mail on Sunday newspapers.