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Role of sleep-related brain activity in clearing toxic proteins and preventing Alzheimer s disease

E-Mail IMAGE: The global brain signal in Alzheimer s disease patients is associated with weaker cerebrospinal fluid flow as compared with healthy controls view more Credit: Feng Han and Xiao Liu @ The Pennsylvania State University Evidence of sleep-dependent low-frequency (PLOS Biology by Xiao Liu and colleagues at The Pennsylvania State University. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating patients. The development of Alzheimer s disease is believed to be driven by the buildup of the toxic proteins amyloid-β and tau in the brain. The brain s glymphatic system plays a crucial role in clearing these toxins and previous work has shown a possible relationship between sleep-dependent global brain activity and the glymphatic system by showing this activity is coupled by cerebrospinal fluid f

University of southern californiaUnited statesSouth koreaXiao liuEli lillyMichael weinerFoundation for the national institutes of healthDepartment of defenseNeurorx researchMeso scale diagnosticsNational institute of biomedical imagingMerck co incPfizer incLaboratory for neuro imagingYork universityRoche ltd

Novartis reports one year results of Phase III MERLIN study evaluating BEOVU® every four week dosing and provides update on BEOVU clinical program

/PRNewswire/ Today, Novartis reported the first interpretable year one results of the Phase III MERLIN study, a two-year study initiated in H2 2018,.

United statesUnited kingdomLookeren campagneBeovu baselJohn tsaiHealth qual life outcomesNational eye instituteNational health insurance pricingTechnologies in healthWorld health organizationGlobal head of drug developmentCanadian drug expert committee recommendationExchange commissionNj novartis pharmaceuticals corporationNovartis pharmaceuticals corporationCanadian agency for drugs

Monitoring the potency of cell therapies using bioelectronic assays

Monitoring the potency of cell therapies using bioelectronic assays 2 Chimeric antigen receptor (CAR) T and natural killer (NK) therapies may become the future of cancer treatment. Dr Jim Ross explains how bioelectronic assays are a non-invasive, label-free approach built for real-time, dynamic assessment of cell therapy potency. Personalised medicine is now within reach for thousands of cancer patients thanks to immunotherapies such as CAR T cells. This cell therapy involves training a patient’s immune system through genetic engineering to recognise tumour cells as foreign bodies and attack them directly, without attacking healthy tissue. In 2017, the US Food and Drug Administration (FDA) approved Kymriah, the first CAR T-cell therapy, for the treatment of B-cell acute lymphoblastic leukaemia. Now, patients across the US can access the treatment at any one of over 130 treatment centers.

United statesJim rossAxion biosystemsLohitash karumbaiahNovartis pharmaceuticals corporationDrug administrationCancer research instituteAssociate professorRegenerative medicine lohitash karumbaiahChief technology officerஒன்றுபட்டது மாநிலங்களில்ஜிம் ரோஸ்அச்சு உயிர் அமைப்புகள்நோவர்த்திச் மருந்துகள் நிறுவனம்புற்றுநோய் ஆராய்ச்சி நிறுவனம்இணை ப்ரொஃபெஸர்

Novartis to unveil new data at ASCO and EHA from its robust portfolio, including overall survival in prostate and breast cancer

Novartis to unveil new data at ASCO and EHA from its robust portfolio, including overall survival in prostate and breast cancer
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United statesIsabella zinckSamir shahJulie masowThomas hungerbuehlerSloan simpsonSusanne schaffertFiona phillipsAmerican society of clinical oncologyNovartis institutes for biomedical researchAstex pharmaceuticalsEuropean hematology associationNovartis strategy financial communicationsNovartis oncology communicationsNovartis us external communicationsExchange commission