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Sequana Medical NV: Transparency Notifications from Shareholders Ghent, BELGIUM - 23 February 2021 - Sequana Medical NV (Euronext Brussels: SEQUA) (the Company or Sequana Medical ), an innovator in the treatment of diuretic-resistant fluid overload in liver disease, malignant ascites and heart failure, announces today in accordance with Article 14 of the Belgian Act of 2 May 2007 on the disclosure of major participations in issuers of which shares are admitted to trading on a regulated market and regarding miscellaneous provisions (the Belgian Transparency Act ) that it received transparency notifications from the shareholders listed below, notifying the number of voting rights attached to shares mentioned next to their respective names in the table below.

United statesChris maggosDina chayaBelgian companiesSequana holdingNeomed iv extension limitedNeomed management jersey limitedBelgian financial servicesHealth economics fund managementNeomed innovationv limitedNeomed iv extension limited innovationManagement groupCompany or sequanamedicalNeomed management jerseyEuronext brusselsBelgian act