IMAGE: Biofabrication of multicompartmental hydrogel fibers for formation of multiscale biomimetic constructs. view more
Credit: Mohamadmahdi Samandari, Fatemeh Alipanah, Keivan Majidzadeh-A, Mario M. Alvarez, Grissel Trujillo-de Santiago, and Ali Tamayol
WASHINGTON, May 5, 2021 - 3D bioprinting can create engineered scaffolds that mimic natural tissue. Controlling the cellular organization within those engineered scaffolds for regenerative applications is a complex and challenging process.
Cell tissues tend to be highly ordered in terms of spatial distribution and alignment, so bioengineered cellular scaffolds for tissue engineering applications must closely resemble this orientation to be able to perform like natural tissue.
In
Applied Physics Reviews, from AIP Publishing, an international research team describes its approach for directing cell orientation within deposited hydrogel fibers via a method called multicompartmental bioprinting.
Researchers have identified a set of genes, called clock genes, that control circadian rhythms. But a more complicated gene network than previously known appears related to these rhythms. In Applied Physics Reviews, scientists detail a statistical model they are using to help identify the genes involved in this network. With help from other disciplines, they hope to fully understand how these genes work together to make different people more productive at different times of day.
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IMAGE: Surface, cross-sectional optical/SEM images showing the uniaxially aligned surface patterns and microchannels within the struts of the fabricated collagen scaffolds. A schematic showing the osteogenesis and angiogenesis of the fabrication. view more
Credit: Hanjun Hwangbo, Hyeongjin Lee
WASHINGTON, May 4, 2021 Spinal fusion is frequently performed to restore spinal stability in patients with spinal diseases, such as spinal stenosis, vertebral fractures, progressive deformities, and instability. In the past two decades, there has been marked increase in the number of people over 65 years in age who have needed spinal fusion surgery.
While autogenous bone grafts have long been considered the reference standard for spinal fusion, painful pseudoarthrosis remains a leading cause of poor clinical outcomes. Many researchers have consequently focused on trying to create a biomimetic scaffold that induces vascularization to enable bone tissue regeneration and
Circadian rhythm-controlling clock genes could be tweaked to alter sleep
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Scientists may soon by able to influence a person s clock genes and alter their innate sleep patterns. Photo by Wokandapix/Pixabay
May 4 (UPI) Researchers have identified a complex combination of genes that control the human body s circadian rhythms, the rhythms that help sync a variety of biological processes with both day-night and seasonal patterns.
Scientists were able to identify the network of clock genes, described Tuesday in the journal Applied Physics Reviews, using an advanced statistical model.
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With assistance from geneticists, biologists and medical researchers, the authors of the new paper hope to work out how individual clock genes work together to influence circadian rhythms.
Image Credit: Marko Aliaksandr/Shutterstock.com
Semiconductors are a widely used class of materials with electrical conductivities that fall between that of conductors and insulators. What has made doped versions of these materials the cornerstone of modern electronics is their ability to control the flow of electrons as part of a circuit, switching on and off as required, with a minimal physical device footprint.
Controlling the flow of electrons is not the only interesting application of semiconductor materials. Some semiconducting materials can be used to either convert electricity into light or, to do the reverse, converting absorbed light energy into electrical charge.