2
1Department of Breast Surgical Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China;
2The 2nd Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China
Correspondence: Liqiang Qi
Department of Breast Surgical Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing, 100021, People’s Republic of China
Tel +86-10-67781331
Purpose: circHIPK3 has carcinogenic or anti-tumor effects on different cancers. However, there is no relevant research showing whether circHIPK3 was involved in breast cancer (BCa). In this research, the aim was to analyze the function and possible molecular mechanism of circHIPK3 in BCa.
↓ cleavage residues indicate that the NDV isolates correspond to mesogenic/velogenic pathotypes.
Figure 2 Deduced amino acid sequence alignment of F gene sequences of NDV strains isolated from Ethiopia. Names of strains are shown on the left-hand side of the figure. Identification with the reference La Sota (genotype II) vaccine strains is indicated by dots. They indicate the cleavage site of the deduced aa sequence of the F gene. X indicates an ambiguous aa sequence.
Abbreviations: Eth, Ethiopia; Chk, chicken.
Genetic Distance
The Ethiopian NDV isolates have a within-group genetic distance of 10.16% and a between-group genetic distance of 25.1% (Table 2). These isolates are grouped for ease of presentation as published by authors: group1 (sequences characterized in this study from the central part of the country), group 2 from the central part of Ethiopia,
Excessive inflammation is a characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly in patients that are hospitalized with coronavirus disease 2019 (COVID-19). Here, Hoepel et al. investigated how human antibodies specific to SARS-CoV-2 spike protein may contribute to exacerbated inflammation. The authors found that spike protein–specific antibodies from patients with COVID-19 who were hospitalized had altered glycosylation, with an enrichment in low-fucosylated antibodies. These antibodies were able to activate human macrophages in vitro to secrete proinflammatory cytokines. Thus, altered antibody glycosylation may contribute to disease severity in COVID-19.
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that e
All data are presented as the Mean ± SD. The Student’s
t-test or the Pearson’s Chi-square test/Fisher’s exact test was utilized to analyze difference between groups with continuous variables or categorical variables, respectively. The Kaplan-Meier method and the Log rank test were applied for overall survival with chondrosarcoma patients. Univariate and multivariate analyses of clinicopathological factors, ZNF395 level and overall survival were performed using Cox regression model. Statistical analyses were performed using SPSS (SPSS, Chicago, IL, USA) and
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