Melioidosis is a life-threatening infectious disease caused by the gram-negative bacillus
Burkholderia pseudomallei. An effective vaccine is needed, but data on protective immune responses in human melioidosis are lacking. We used ELISA and an antibody-dependent cellular phagocytosis assay to identify the major features of protective antibodies in patients with acute melioidosis in Thailand. We found that high levels of
B. pseudomallei–specific IgG2 are associated with protection against death in a multivariable logistic regression analysis adjusting for age, diabetes, renal disease, and neutrophil count. Serum from melioidosis survivors enhanced bacteria uptake into human monocytes expressing FcγRIIa-H/R131, an intermediate-affinity IgG2-receptor, compared with serum from nonsurvivors. We did not find this enhancement when using monocytes carrying the low IgG2–affinity FcγRIIa-R131 allele. The findings indicate the importance of IgG2 in protection against death in human me
Thermo Fisher Scientific Acquires Programmable Dye Platform Pioneer Phitonex
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WALTHAM, Mass., Dec. 31, 2020 /PRNewswire/ Thermo Fisher Scientific, the world leader in serving science, today announced it has completed the acquisition of Phitonex, Inc., a Durham, North Carolina-based company that has pioneered a spectral dye platform for high-resolution biology applications designed to accelerate research and development in cell therapy, immuno-oncology and immunology research. Phitonex s product offering will enable Thermo Fisher to offer greater flow cytometry and imaging multiplexing capabilities to meet evolving customer needs in protein and cell analysis research.
The innovative platform, called the Phiton, acts as a structure that can maintain a higher number of fluorescent dyes in very specific ways, allowing researchers the ability to analyze single cells in high resolution. Consequently, it enables researchers to a
Thermo Fisher Scientific Announces Redemption of Senior Notes
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WALTHAM, Mass., Dec. 30, 2020 /PRNewswire/ Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, today announced that on December 31, 2020, it will give notice of its intention to redeem the following Senior Notes, representing an aggregate total principal amount of approximately $2.6 billion, on January 15, 2021 (the Redemption Date ):
€0.5 billion aggregate principal amount of 2.150% Senior Notes due 2022 (NYSE: TMO 22A) (the 2022 Notes )
$1.0 billion aggregate principal amount of 3.000% Senior Notes due 2023 (the 2023 Notes )
$1.0 billion aggregate principal amount of 4.150% Senior Notes due 2024 (the 2024 Notes and, together with the 2022 Notes and the 2023 Notes, the Notes )
Boys & Girls Clubs of America and Thermo Fisher Scientific Partner to Provide Virtual STEM Education Programming for Youth Globally
Timely program enables millions to learn and engage online and build life-long interest in science
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WALTHAM, Mass., Dec. 22, 2020 /PRNewswire/ Boys & Girls Clubs of America and Thermo Fisher Scientific, the world leader in serving science, today announced a partnership to make virtual STEM education programming available to millions of young people around the world.
Thermo Fisher is providing financial support and content expertise for the DIY STEM curriculum, now available through
MyFuture, Boys & Girls Clubs of America s online program that allows members a safe, fun digital platform to showcase their work and earn recognition in the form of stars, badges and master badges. Unique offerings include interactive videos of scientists working in real labs, games and other content specially