E-Mail
Modern immunotherapeutic anti-cancer drugs support a natural mechanism of the immune system to inhibit the growth of cancer cells. They dock onto a specific receptor of the killer cell and prevent it from being switched off by the cancer cells. This is a complex molecular process, which is known but has not yet been fully understood. In a molecular dynamics study conducted by the group led by medical information scientist Wolfgang Schreiner and gynaecologists Heinz Kölbl and Georg Pfeiler from MedUni Vienna, working with biosimulation expert Chris Oostenbrink from the University of Natural Resources and Applied Life Sciences (Boku) Vienna, has now, for the first time, analysed this mechanism for the drugs nivolumab and pembrolizumab. It was found that tiny molecular motions are of key significance. The study has been published in the leading journal
New method replicates bone tissue complexity, bone remodeling processes
A multidisciplinary team of researchers at the University of Massachusetts Amherst s Institute for Applied Life Sciences (IALS) have developed a technique to replicate bone tissue complexity and bone remodeling processes.
This breakthrough could help researchers further their study of bone biology and assist in improving development of drugs for osteoporosis.
Published in
Science Advances, the researchers developed a new biomaterial they call demineralized bone paper. The team includes Jungwoo Lee, Yongkuk Park, Ryan Carpenter, chemical engineering; Eugene Cheong, biochemistry and microbiology; Jun-Goo Kwak, molecular and cellular biology graduate program; and Jae-Hyuck Shim of the UMass Medical School in Worcester.
Bone Remodeling Technique Could Lead to New Osteoporosis Therapies
Source: Luis Alvarez/Getty Images
January 27, 2021
Share
Scientists at the University of Massachusetts (UMass) Amherst’s Institute for Applied Life Sciences (IALS) say they have developed a technique to replicate bone tissue complexity and bone remodeling processes. They believe their work could help researchers further their study of bone biology and assist in improving development of drugs for osteoporosis.
Science Advances.
“Trabecular bone maintains physiological homeostasis and consistent structure and mass through repeated cycles of bone remodeling by means of tightly localized regulation. The molecular and cellular processes that regulate localized bone remodeling are poorly understood because of a lack of relevant experimental models,” write the investigators.
E-Mail
A multidisciplinary team of researchers at the University of Massachusetts Amherst s Institute for Applied Life Sciences (IALS) have developed a technique to replicate bone tissue complexity and bone remodeling processes. This breakthrough could help researchers further their study of bone biology and assist in improving development of drugs for osteoporosis.
Published in
Science Advances, the researchers developed a new biomaterial they call demineralized bone paper. The team includes Jungwoo Lee, Yongkuk Park, Ryan Carpenter, chemical engineering; Eugene Cheong, biochemistry and microbiology; Jun-Goo Kwak, molecular and cellular biology graduate program; and Jae-Hyuck Shim of the UMass Medical School in Worcester.
A multidisciplinary team of researchers at UMass Amherst’s Institute for Applied Life Sciences (IALS) have developed a technique to replicate bone tissue complexity and bone remodeling processes. This breakthrough could help researchers further their study of bone biology and assist in improving development of drugs for osteoporosis.