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Quantum Leap Healthcare Collaborative Concludes Cenicriviroc Not Likely to Reduce Time to Recovery or Mortality in Critically Ill Patients in I-SPY COVID Trial

Share this article Share this article SAN FRANCISCO, April 28, 2021 /PRNewswire/ Quantum Leap Healthcare Collaborative (QLHC), the sponsor of the I-SPY COVID Trial, today announced that cenicriviroc (CVC) has been dropped from the trial due to futility, based on the low likelihood of success. CVC was chosen for testing because it is a CCR2/5 inhibitor, which has been hypothesized to potentially prevent fibrosis linked to the inflammation that accompanies critical illness associated with COVID-19. The I-SPY COVID Trial is a phase II, open label, adaptive platform trial being conducted in critically ill COVID-19 patients who are receiving high-flow oxygen or mechanical ventilation. The trial was designed to rapidly screen agents to find those with the best chance of reducing time to recovery (defined as reduction in oxygen demand) by approximately 50% and reducing risk of death. The I-SPY COVID Trial identified the initial agents for the study through a unique partnership with th

CDC says many Americans can now go outside without a mask | News, Sports, Jobs

CDC says many Americans can now go outside without a mask | News, Sports, Jobs
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CDC eases mask guidelines for vaccinated citizens | News, Sports, Jobs

Apr 28, 2021 NEW YORK (AP) The Centers for Disease Control and Prevention eased its guidelines Tuesday on the wearing of masks outdoors, saying fully vaccinated Americans don’t need to cover their faces anymore unless they are in a big crowd of strangers. And those who are unvaccinated can go outside without masks in some situations, too. The new guidance represents another carefully calibrated step on the road back to normal from the coronavirus outbreak that has killed over 570,000 people in U.S. For most of the past year, the CDC had been advising Americans to wear masks outdoors if they are within 6 feet of one another.

CDC says many now can go outside without a mask

CDC says many now can go outside without a mask Mike Stobbe Associated Press and David C.L. Bauer Journal-Courier April 28, 2021 FacebookTwitterEmail And those who are unvaccinated also can go outside without masks in some situations. The new guidance represents another carefully calibrated step on the road back to normal from the coronavirus outbreak that has killed more than 570,000 people in U.S. For most of the past year, the CDC had been advising Americans to wear masks outdoors if they are within 6 feet of one another. “Today, I hope, is a day when we can take another step back to the normalcy of before,” CDC Director Dr. Rochelle Walensky said. “Over the past year, we have spent a lot of time telling Americans what you can’t do. Today, I am going to tell you some of the things you can do, if you are fully vaccinated.”

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