(0) Primary study endpoint demonstrates 86 percent response rate for patients receiving co-therapy of KRYSTEXXA and mycophenolate mofetil
Horizon Therapeutics plc (Nasdaq: HZNP) announced the publication of data from the first randomized controlled clinical trial (RCT) of KRYSTEXXA (pegloticase injection) concomitantly used with an immunomodulator, mycophenolate mofetil, in
Arthritis Rheumatology [doi.org/10.1002/art.41731].
The Reducing Immunogenicity of Pegloticase (RECIPE) trial demonstrated that 86 percent of patients (19 of 22) receiving co-therapy of KRYSTEXXA with the immunomodulator mycophenolate mofetil achieved serum uric acid (sUA) 6 mg/dL at 12 weeks, the primary study endpoint, compared to 40 percent of patients (4 of 10) receiving KRYSTEXXA monotherapy. The safety and efficacy of KRYSTEXXA co-prescribed with mycophenolate mofetil has not been established by any health authorities.
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As the U.S. races to vaccinate its population, the development of better COVID-19 vaccines has already begun. // Government Pharmaceutical Organization of Thailand via Agence France-Presse/Getty Images
The three COVID-19 vaccines available in the United States are safe and effective and were made in record time.
But they aren t ideal.
An ideal vaccine besides being safe and effective would have a few other desirable characteristics, says Deborah Fuller, a vaccine researcher at the University of Washington.
Such a vaccine would be administered in a single shot, be room temperature stable, work in all demographics and, even pushed beyond that, ideally be self-administered, she says.
More contagious UK variant of COVID-19 becoming dominant in Alabama
Updated 11:29 AM;
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A more contagious variant of COVID-19 from the United Kingdom has swept through Alabama in the last two months.
Researchers at the University of Alabama at Birmingham, home to the primary lab sequencing strains of the disease in the state, estimate about 40 percent of cases are now the highly contagious UK variant. That’s up from about 1 percent of cases in February.
Dr. Sixto Leal, professor of laboratory medicine at UAB, said existing COVID vaccines appear to be effective against the UK variant, but that could evolve.
Researchers Urge Second COVID Vaccine Dose for Infliximab Users medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.
Simone Grimes named chief financial officer at Acadia Insurance
Simone Grimes
Simone Grimes has been appointed chief financial officer of Acadia Insurance in Westbrook. She succeeds Charlie Hamblen, who will retire later this year. Grimes has diverse senior leadership experience in the worlds of finance and insurance, previously working at PricewaterhouseCoopers, then as a regional vice president at a national insurance carrier and most recently serving as the deputy chief operating officer and senior strategy executive at the Federal Housing Finance Agency in Washington, DC.
Eric Rasmussen
Gawron Turgeon Architects, of Scarborough, has announced two new hires to its team.