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Date Time A new mechanism protects against cancer cell migration G3BP proteins inhibit the metabolic driver MTOR, a signaling protein that plays a central role in tumor diseases and developmental disorders of the brain. This is reported in the journal Cell. The study was led by scientists from the University of Innsbruck and the German Cancer Research Center together with the Medical University of Innsbruck and a European network. The signaling protein MTOR (Mechanistic Target of Rapamycin) is a sensor for nutrients such as amino acids and sugars. When sufficient nutrients are available, MTOR boosts metabolism and ensures that sufficient energy and building blocks are available for the growth and function of all cells in the human body. “Because MTOR is such a central switch for metabolism, errors in its activation lead to serious diseases. These include cancers associated with excessive metabolic activity, cell growth and proliferation. Dysregulated MTOR also causes malformatio

Nordrhein westfalenKathrin thedieckLukasa huberRamos pittolChristiane opitzCadena sandovalGerman research foundationUniversity of innsbruckGenomics england research consortiumEuropean unionAustrian science fundGerman tuberous sclerosis foundationGerman cancer research centerMedical universityMechanistic targetAlso lukas