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The micro-environment of breast cancer in three dimensions

 E-Mail IMAGE: Penn State researchers 3D bioprinted breast cancer tumors (green) and cultivated their supportive microenvironments (purple) to better understand how they interact with one another. Image: view more  Credit: Ozbolat Lab/Penn State Cancerous tumors thrive on blood, extending their roots deep into the fabric of the tissue of their host. They alter the genetics of surrounding cells and evolve to avoid the protective attacks of immune cells. Now, Penn State researchers have developed a way to study the relationship between solid, difficult-to-treat tumors and the microenvironment they create to support their growth. The method has the potential to act as a testbed for drugs and other anticancer treatments, according to Ibrahim T. Ozbolat, associate professor of engineering science and mechanics and biomedical engineering, who led the research. The details of the approach were published in

Shoreline Biome Launches NanoID High-Resolution Microbiome Kits and Software using Patented Long Amplicon Technology for Oxford Nanopore Systems

Shoreline Biome Launches NanoID High-Resolution Microbiome Kits and Software using Patented Long Amplicon Technology for Oxford Nanopore Systems Share Article Shoreline Complete NanoID kits are the perfect solution for microbiome researchers seeking high-resolution microbiome data using Shoreline Biome’s long amplicon technology FARMINGTON, Conn. (PRWEB) March 16, 2021 Shoreline Biome, a microbiome research company that develops tools for characterizing microbiome populations down to the strain level, recently unveiled a powerful new analysis solution for Oxford Nanopore Systems. Shoreline Complete NanoID™ is the fastest and most complete microbiome sample prep kit for long-read NGS analysis for Oxford Nanopore Systems. Leave no microbe behind from any complex microbial mixture using the patented lysis /DNA purification step without bead beating. Smart primer design and unique dual-end barcoding reduces amp

Researcher Under FBI Investigation for Allegedly Hiding Ties to China

Researcher Under FBI Investigation for Allegedly Hiding Ties to China A Chinese researcher who once worked at The Jackson Laboratory is under FBI investigation, for allegedly failing to disclose his financial ties to China in applications for U.S. government funding. Ruan Yijun, a geneticist, failed to disclose his participation in a Chinese state-sponsored recruitment program called the Thousand Talents program and his collaboration agreement with China’s state-run Shenzhen People’s Hospital, according to an FBI affidavit unsealed on Mar. 2. The affidavit was filed in federal court in Bangor, Maine, on Dec. 30 last year. The Jackson Laboratory (JAX) is a nonprofit biomedical research institution based in Maine. Its mission is to discover genetic solutions for treating human diseases. According to Ruan’s curriculum vitae (pdf) available on the JAX website, he began working at JAX’s genomics research center at the campus of the University of Connecticut Health Center in 20

Building a brain: Pioneering study reveals principles of brain tissue structure, assembly

Loading video. VIDEO: Volumetric reconstruction of the L4 C. elegans neuropil (from EM serial sections) with neurons from the four strata highlighted (S1-Red, S2-Purple, S3-Blue, S4-Green). view more  Credit: Mark Moyle et al., Nature, 2021. WOODS HOLE, Mass. Understanding how the brain works is a paramount goal of medical science. But with its billions of tightly packed, intermingled neurons, the human brain is dauntingly difficult to visualize and map, which can provide the route to therapies for long-intractable disorders. In a major advance published next week in Nature, scientists for the first time report the structure of a fundamental type of tissue organization in brains, called neuropil, as well as the developmental pathways that lead to neuropil assembly in the roundworm

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