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Study addresses glycosylation concerns in SARS-CoV-2 vaccine design
An international team of researchers has found that glycosylation patterns are conserved across the native spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – and the recombinant spike proteins made in laboratories for use in vaccines.
The spike protein, which SARS-CoV-2 uses to bind to and infect cells, is the main target of neutralizing antibodies following natural infection with the virus or vaccination.
A central tenet in vaccine design is the presentation of native-like antigens that will induce protective immunity. The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity between the many different vaccine candidates under investigation, says Max Crispin from the University of Southampton in the UK and colleagues.
The company behind the Novavax jab has announced that the vaccine is 86% effective against the Kent variant. The news comes after a study enrolled more than 15,000 participants aged between 18 and 84, including 27% over the age of 65. According to results from the phase three trial in the UK, the jab also offers 100% protection against severe disease, including all hospital admission and death. Results show that it is 96% effective in preventing.
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The finals of the 36th America’s Cup pit the defending champion Emirates Team New Zealand against the contending crew of Luna Rossa Prada Pirelli from Italy.
The best-of-13 battle, sailed in waters off the coast of Auckland, also pits University of Southampton graduates against each other as alumni feature in both teams. Luna Rossa’s Construction Manager is Julian Meunier who completed his MSc in Maritime Engineering, Yacht and Small Craft in 2007 at Southampton and one of the team’s Aerodynamic Analysts is Nicholas Carabelli who graduated with the same degree in 2018.
The design of Team New Zealand’s entry Te Rehautai – which means ‘sea spra’ in Maori – has been led by Technical Director and Southampton graduate Dan Bernasconi. He’s joined at Team New Zealand by fellow Southampton alumni Thomas Khyn, another MSc Maritime, Yacht and Small Craft graduate from 2007, and Guillaume Verdier who studied Naval Architecture and graduated in 1995.