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Synthetic Oligonucleotides Regulatory Analytical Manufacturing Considerations

Synthetic Oligonucleotides: Regulatory, Analytical & Manufacturing Considerations By Maura Kibbey, Ph.D., and Nick Healy, U.S. Pharmacopeia (USP) After decades of investment, research, and development, the therapeutic value of oligonucleotides has started to materialize. Dozens of developers now have dedicated pipelines for diverse indications such as oncology, central nervous system diseases, cardiometabolic disorders, liver diseases, and viral infections, including COVID-19. A search for “oligonucleotide” on ClinicalTrials.gov returned more than 50 active studies. Advances in analytical methods are helping to support these pipelines. Across the development and release landscapes, methods continue to refine, streamline, and support the development of oligonucleotides from new applications of nuclear magnetic resonance (NMR) spectroscopy that are pushing the boundaries of what can be accomplished in development, to innovative platform approaches for specification and release t

For many, insurance doesn t prevent high costs from prescriptions

84 Half of Americans take no prescription drugs. At the other end of the spectrum are people like Karen Milligan. She needs several drugs and pays. Half of Americans take no prescription drugs. At the other end of the spectrum are people like Karen Milligan. She needs several drugs and pays a lot for them. She has dealt with multiple sclerosis for three decades. It’s disease of the central nervous system with no cure.  At 65, Karen is seeing her drug costs continue to increase, even for the same drug she has been taking for years. Her total out-of-pocket spending  for medications is running about $9,000 a year, though she’s covered by Medicare. Her husband, Greg, says the MS drug Aubagio has gotten significantly more expensive for her.

Covid vaccine side effects second dose

Side effects are mild but more frequent with a second dose Author: Jerry Carnes Updated: 10:52 AM EDT April 12, 2021 ATLANTA ATLANTA – Not everyone feels the achiness and headache that sometimes comes from a COVID-19 vaccine, but more often than not it’s the second dose that results in side effects. The coronavirus vaccine can make you feel as if you’ve come down with the very virus you’re trying to combat. Muscle aches and even a fever are not uncommon. When it comes to the double-dose vaccines, it’s more likely to happen after the second shot. “Our bodies launch an immune response to a foreign substance just like it would if we got an actual infection,” says Dr. Ashley Hannings of the University of Georgia’s College of Pharmacy.

Thrifty Mac Pharmacy Delights Patients and Staff

Thrifty Mac Pharmacy Delights Patients and Staff
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