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A small drug molecule that appears to protect normal tissue from the damaging effects of radiation, may simultaneously be able to boost the cancer-killing effect of radiation therapy, according to a new study led by scientists at University of Iowa, University of Texas Southwestern Medical Center, and Galera Therapeutics, Inc.
The study, published online May 12 in
Science Translational Medicine, suggests that the drug s dual effect is based on a fundamental difference between the ability of cancer cells and healthy cells to withstand the damaging effects of a highly reactive molecule called hydrogen peroxide, which is produced during the dismutation of superoxide.
New Low-Dose Combination Therapy Blocks Cancer Metastasis in Mice
May 12, 2021
The main obstacles that lead to clinical failure in cancer treatment are the development of resistance to chemotherapy and a rise in invasive characteristics in cancer tumor cells due to prolonged chemotherapeutic processes. A new mouse study reveals that low doses of a four-drug combination help prevent the spread of cancer without triggering drug resistance or recurrence by simultaneously targeting multiple pathways within a metastasis-promoting network.
The findings are published in the journal
eLife in a paper titled, “Limited inhibition of multiple nodes in a driver network blocks metastasis,” and led by researchers at the University of Chicago, the University of São Paulo in Brazil, the University of North Carolina, and the University of Texas Southwestern Medical Center.
Ready. Set. Keep going. The race is still on to vaccinate Americans as Covid-19 variants crop up and a long summer in the U.S. looms. Dr. Anthony Fauci urged members of the Senate Health, Education, Labor and Pension Committee on Tuesday to increase vaccination rates if they want to see a return of pre-pandemic life. (Screenshot via Courthouse News)
WASHINGTON (CN) Shutting down conspiracy theories with aplomb while offering his characteristically blunt assessment of the challenges that still lay in the global war against Covid-19, Dr. Anthony Fauci told members of a Senate health committee that the key lies in greater vaccination rates.
This article is a collaboration between MedPage Today and:
Identifying esophageal adenocarcinoma (EAC) in patients with Barrett s esophagus can improve survival in this population, but some lesions are missed at initial endoscopy.
In a systematic review and meta-analysis recently published in
Clinical Gastroenterology and Hepatology, a group led by Tarek Sawas, MD, MPH, of the University of Texas Southwestern Medical Center in Dallas, and Sachin Wani, MD, of the University of Colorado Anschutz Medical Campus in Aurora, estimated the proportion of post-endoscopy esophageal adenocarcinoma (PEEC) arising in the first year after an index diagnosis of non-dysplastic Barrett s esophagus.
Data came from 52 studies including 145,726 patients with a median follow-up of 4.8 years. What Sawas, Wani, and their colleagues found was disturbing, and they elaborated on this in the following interview with the