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Novel method may overcome current limitations in mouse bone marrow transplantation models To study the immune system in human health and disease, scientists commonly use the genetic manipulation of mouse hematopoietic stem and progenitor cells (HSPCs) as a powerful model system. These studies have been extremely valuable in the fight against a number of human diseases. However, the current procedures are complex, time-consuming, and expensive. In a new study published in NATURE COMMUNICATIONS, researchers at the University of Tsukuba have developed a novel technique that has the potential to overcome the limitations associated with these models, which are known as bone marrow (BM) chimeric mice. This system allows scientists to observe and investigate how genetic alterations affect immune cell phenotypes and behaviors in a physiological setting.

Satoshi yamazakiEmily hendersonUniversity of tsukubaசதோஷி யமாஜாக்கிஎமிலி ஹென்டர்சன்பல்கலைக்கழகம் ஆஃப் ட்சூகுபா