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Enrico Bonadio

Enrico Bonadio
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Despite dip in Covid death rate, no room for laxity

Cancer cell vulnerability points to potential treatment path for aggressive disease

 E-Mail Unravelling the unique characteristics of cancer cells and finding less-harmful ways to stop their growth have long been a focus for cancer researchers worldwide. New findings, reported in Nature Communications, describe the discovery of a unique dependence of cancer cells on a particular protein, which could lead to desperately needed treatment for hard-to-treat cancers. The publication caps off a series of groundbreaking studies appearing in Nature journals over the last month by members of a powerful international research collaboration. Lead author and University of Vermont (UVM) Cancer Center researcher Jason Stumpff, Ph.D., has spent over two decades studying how cells divide and how mistakes in this process contribute to diseases, such as cancer. His recent work has enhanced understanding of the role of a protein called KIF18A in driving cell division. In these new studies, Stumpff s lab demonstrates that cancer cells, with the type of abnormalities seen in agg

UVM discovery of cancer cell vulnerability identifies potential treatment target

  Image of a triple negative breast cancer cell undergoing abnormal division after inhibition of KIF18A. (Credit: Cindy Fonseca, Stumpff Lab, UVM) Vermont Business Magazine Unraveling the unique characteristics of cancer cells and finding less-harmful ways to stop their growth have long been a focus for cancer researchers worldwide. New findings, reported today in Nature Communications, describe the discovery of a unique dependence of cancer cells on a particular protein, which could lead to desperately-needed treatment for hard-to-treat cancers. The publication caps off a series of groundbreaking studies appearing in Nature journals over the last month by members of a powerful international research collaboration.

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