Globally, there is an urgency to develop effective, low-cost therapeutic interventions for coronavirus disease 2019 (COVID-19). We previously generated the stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21). Using Syrian hamsters that model moderate to severe COVID-19 disease, we demonstrate the high efficacy of PiN-21 to prevent and treat SARS-CoV-2 infection. Intranasal delivery of PiN-21 at 0.6 mg/kg protects infected animals from weight loss and substantially reduces viral burdens in both lower and upper airways compared to control. Aerosol delivery of PiN-21 facilitates deposition throughout the respiratory tract and dose minimization to 0.2 mg/kg. Inhalation treatment quickly reverses animals’ weight loss after infection, decreases lung viral titers by 6 logs leading to drastically mitigated lung pathology, and prevents viral pneumonia. Combined with the marked stability and low production cost, this innovative therapy may provide a convenient and cos
This 10-step digital detox will help you break up with Facebook
How to kick-off a “Digital Detox” and break up with social media
At their best, social media platforms like Facebook, Twitter, Instagram and Snapchat can serve as a constant link with our friends and family. We rely on them to keep us connected and up-to-date, while giving us the opportunity to share both validation and inspiration (thank you, Pinterest). That said, digital overstimulation – especially in a time when up-to-the-minute information is free and unfiltered – is taking a toll on our health, both mentally and physically. A study from the University of Pittsburgh’s Center for Research on Media, Technology and Health found that using multiple social media platforms increased the risk of depression and anxiety in participants, especially among those using seven to 11 platforms, compared to peers who used no more than two. And apparently, we’re conscious of at least some of these negative side effec
Using Bulk Purchasing To Lower Prescription Drug Prices Getty/Andrew Lichtenstein
An elderly women begins her day taking her daily prescription medicine on December 24, 2017, in Phoenix, Arizona.
Colin Seeberger
Introduction and summary
COVID-19 has highlighted the importance of an effective government response to infectious diseases, epidemics, and pandemics. In the United States, the initial federal response to the coronavirus crisis was insufficient, causing up to an estimated 180,000 avoidable deaths.
1 And as the vaccine rollout continues to expand under increased federal efforts, the government must consider the tools it has to address not only COVID-19 but also pandemics and epidemics more broadly.
SEATTLE, May 04, 2021, (PHARMIWEB) Saudi Arabia pharmaceutical drugs market growth is driven by various factors such as population growth, investment of companies in halal pharmaceuticals, decrease in fertility rates, and increase in life expectancy. The market is witnessing increasing investments by major market p.