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Researchers Identify a New, Vital Player in Graft-Versus-Host Disease and Organ Transplant Rejection

Researchers Identify a New, Vital Player in Graft-Versus-Host Disease and Organ Transplant Rejection How one long noncoding RNA could help improve outcomes in bone marrow and solid organ transplantation. Credit: Michigan Medicine A long noncoding RNA whose function was previously unknown turns out to play a vital role in mobilizing the immune response following a bone marrow transplant or solid organ transplantation. This RNA molecule, cataloged in scientific databases simply as Linc00402, helps activate immune defenders known as T cells in response to the presence of foreign human cells, according to a new study by researchers at the University of Michigan Rogel Cancer Center and Michigan Medicine.

A new, vital player in graft-versus-host disease and organ transplant rejection

 E-Mail A long noncoding RNA whose function was previously unknown turns out to play a vital role in mobilizing the immune response following a bone marrow transplant or solid organ transplantation. This RNA molecule, cataloged in scientific databases simply as Linc00402, helps activate immune defenders known as T cells in response to the presence of foreign human cells, according to a new study by researchers at the University of Michigan Rogel Cancer Center and Michigan Medicine. The investigation, which included samples from more than 50 patients who underwent a bone marrow or heart transplant, suggests inhibiting the RNA therapeutically might improve outcomes for transplant recipients. Their findings appear in

A new, vital player in graft-versus-host disease and organ transplant rejection

A new, vital player in graft-versus-host disease and organ transplant rejection
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Volume 62, Issue 1 | Mass Review

Brooklyn, NY, June 19, 2020. Volume 62, Issue 1 SPRING FORWARD, FALL BACK. As mnemonics go, one of the best, as equipment for living, not the recipe we need. Though this issue hits the bookstands the day after we spin the clocks ahead, if springing forward is what you’re looking for, you’ve come to the wrong place. Many things must change, given where we’ve been, yet none of that will happen unless we come to terms with what we’ve learned. And it isn’t the lies, the self-dealing, the rancor, or even, at some level, the damage done, the lives ended, the fortunes ruined, the friends and family lost. All of that still burns, how could it not, and nothing will be forgotten, because how could it be? Yet what is truly essential, what must at last be confronted, was delivered to us drop by drop during this interminable succession of isolated days, a truth that 2020 hindsight cannot not reveal. Though elsewhere there will be other versions, in the US that truth is simple: this co

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